MGP Database

MGP003137

Ontology/Pathway Information

Entrez Gene ID	7077
Gene Name	TIMP metallopeptidase inhibitor 2
Gene Symbol	TIMP2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005604	IEA:Ensembl	C	basement membrane
GO:0009986	IEA:Ensembl	C	cell surface
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IEA:Ensembl	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0030426	IEA:Ensembl	C	growth cone
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0008047	IEA:Ensembl	F	enzyme activator activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0008191	TAS:ProtInc	F	metalloendopeptidase inhibitor activity
GO:0007568	IEA:Ensembl	P	aging
GO:0071310	IEA:Ensembl	P	cellular response to organic substance
GO:0007417	IEA:Ensembl	P	central nervous system development
GO:0022617	TAS:Reactome	P	extracellular matrix disassembly
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0010951	TAS:GOC	P	negative regulation of endopeptidase activity
GO:0045930	IEA:Ensembl	P	negative regulation of mitotic cell cycle
GO:0046580	IEA:Ensembl	P	negative regulation of Ras protein signal transduction
GO:0045762	IEA:Ensembl	P	positive regulation of adenylate cyclase activity
GO:0043410	IEA:Ensembl	P	positive regulation of MAPK cascade
GO:0045666	IEA:Ensembl	P	positive regulation of neuron differentiation
GO:0032487	IEA:Ensembl	P	regulation of Rap protein signal transduction
GO:0034097	IEA:Ensembl	P	response to cytokine
GO:0042493	IEA:Ensembl	P	response to drug

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_118682	Activation of Matrix Metalloproteinases
REACT_118572	Degradation of the extracellular matrix
REACT_118779	Extracellular matrix organization