MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003137

UniProt Annotations

Entry Information
Gene NameTIMP metallopeptidase inhibitor 2
Protein EntryTIMP2_HUMAN
UniProt IDP16035
SpeciesHuman
Comments
Comment typeDescription
FunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:2554304, ECO:0000269|PubMed:2793861}.
InductionDown-regulated by TGFB1. {ECO:0000269|PubMed:2380196}.
InteractionP50281:MMP14; NbExp=2; IntAct=EBI-1033507, EBI-992788;
PtmThe activity of TIMP2 is dependent on the presence of disulfide bonds.
SimilarityBelongs to the protease inhibitor I35 (TIMP) family. {ECO:0000305}.
SimilarityContains 1 NTR domain. {ECO:0000255|PROSITE- ProRule:PRU00295}.
Subcellular LocationSecreted.
SubunitInteracts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:12032297, ECO:0000269|PubMed:1655733}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TIMP2ID42572ch17q25.html";
  logo