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MGP003179

Record overview

MGPD IDMGP003179
Gene ID7166
SpeciesHomo sapiens (Human)
Gene Nametryptophan hydroxylase 1
Gene Symbol TPH1
SynonymsTPRH; TRPH;
Alternate namestryptophan 5-hydroxylase 1; L-tryptophan hydroxylase; indoleacetic acid-5-hydroxylase; tryptophan 5-monooxygenase 1; tryptophan hydroxylase (tryptophan 5-monooxygenase);
Chromosome11
Map Location11p15.3-p14
EC Number1.14.16.4
SummaryThis gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
OrthologsView orthologs and multiple alignments for TPH1

Proteins

tryptophan 5-hydroxylase 1
Refseq ID:NP_004170
Protein GI:4759248
UniProt ID:P17752
mRNA ID:NM_004179
Length:444
RefSeq Status:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKED
GMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLL
SKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVK
YNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
 
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