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MGP003179

UniProt Annotations

Entry Information
Gene Nametryptophan hydroxylase 1
Protein EntryTPH1_HUMAN
UniProt IDP17752
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P17752-1; Sequence=Displayed; Name=2; IsoId=P17752-2; Sequence=VSP_000546;
Catalytic ActivityL-tryptophan + tetrahydrobiopterin + O(2) = 5- hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
CofactorName=Fe(2+); Xref=ChEBI:CHEBI:29033;
PathwayAromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
SimilarityBelongs to the biopterin-dependent aromatic amino acid hydroxylase family. {ECO:0000305}.
SimilarityContains 1 ACT domain. {ECO:0000255|PROSITE- ProRule:PRU01007}.
SubunitHomotetramer. {ECO:0000250}.
Tissue SpecificityIsoform 2 seems to be less widely expressed than isoform 1.
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