MGP Database

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MGP003226

Ontology/Pathway Information

Entrez Gene ID7295
Gene Namethioredoxin
Gene Symbol TXN
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:HPACnucleus
GO:0015037 IEA:EnsemblFpeptide disulfide oxidoreductase activity
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0015035 IEA:InterProFprotein disulfide oxidoreductase activity
GO:0032148 IC:ParkinsonsUK-UCLPactivation of protein kinase B activity
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0008283 TAS:ProtIncPcell proliferation
GO:0045454 IEA:EnsemblPcell redox homeostasis
GO:0006928 TAS:ProtIncPcellular component movement
GO:0006662 IEA:InterProPglycerol ether metabolic process
GO:0045087 TAS:ReactomePinnate immune response
GO:1903206 IGI:ParkinsonsUK-UCLPnegative regulation of hydrogen peroxide-induced cell death
GO:0046826 IEA:EnsemblPnegative regulation of protein export from nucleus
GO:0000122 IEA:EnsemblPnegative regulation of transcription from RNA polymerase II promoter
GO:0015949 TAS:ReactomePnucleobase-containing small molecule interconversion
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0055114 IDA:UniProtKBPoxidation-reduction process
GO:0043388 IDA:UniProtKBPpositive regulation of DNA binding
GO:0033138 IGI:ParkinsonsUK-UCLPpositive regulation of peptidyl-serine phosphorylation
GO:0051897 IC:ParkinsonsUK-UCLPpositive regulation of protein kinase B signaling
GO:0033158 IDA:UniProtKBPregulation of protein import into nucleus, translocation
GO:0009314 IDA:UniProtKBPresponse to radiation
GO:0007165 TAS:ProtIncPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_264249Detoxification of Reactive Oxygen Species
REACT_6900Immune System
REACT_75900Inflammasomes
REACT_6802Innate Immune System
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_169436Oxidative Stress Induced Senescence
REACT_21330Synthesis and interconversion of nucleotide di- and triphosphates
REACT_75808The NLRP3 inflammasome
SMP Pathway Links
SMP IDDescription
SMP00535Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144Adenosine Deaminase Deficiency
SMP00167Adenylosuccinate Lyase Deficiency
SMP00168AICA-Ribosiduria
SMP00427Azathioprine Action Pathway
SMP00365Gout or Kelley-Seegmiller Syndrome
SMP00364Lesch-Nyhan Syndrome (LNS)
SMP00428Mercaptopurine Action Pathway
SMP00536Mitochondrial DNA depletion syndrome
SMP00203Molybdenum Cofactor Deficiency
SMP00537Myoadenylate deaminase deficiency
SMP00050Purine Metabolism
SMP00210Purine Nucleoside Phosphorylase Deficiency
SMP00430Thioguanine Action Pathway
SMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512Xanthinuria type I
SMP00513Xanthinuria type II
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