MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003226

UniProt Annotations

Entry Information
Gene Namethioredoxin
Protein EntryTHIO_HUMAN
UniProt IDP10599
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10599-1; Sequence=Displayed; Name=2; IsoId=P10599-2; Sequence=VSP_045607;
FunctionADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
FunctionParticipates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
InductionUp-regulated by ionizing radiation. {ECO:0000269|PubMed:11118054}.
InteractionQ92905:COPS5; NbExp=8; IntAct=EBI-594644, EBI-594661; P00533:EGFR; NbExp=4; IntAct=EBI-594644, EBI-297353; Q99683:MAP3K5; NbExp=2; IntAct=EBI-594644, EBI-476263; Q99836:MYD88; NbExp=4; IntAct=EBI-594644, EBI-447677; P18031:PTPN1; NbExp=2; IntAct=EBI-594644, EBI-968788;
PtmIn case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation. {ECO:0000269|PubMed:19690162}.
PtmIn the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins. {ECO:0000269|PubMed:15246877, ECO:0000269|PubMed:16408020, ECO:0000269|PubMed:17260951, ECO:0000269|PubMed:17606900}.
SimilarityBelongs to the thioredoxin family. {ECO:0000305}.
SimilarityContains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular LocationNucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
SubunitHomodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. {ECO:0000269|PubMed:15246877, ECO:0000269|PubMed:17260951, ECO:0000269|PubMed:19690162, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9369469}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TXNID44354ch9q31.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/txn/";
  logo