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MGP003229

Record overview

MGPD IDMGP003229
Gene ID7298
SpeciesHomo sapiens (Human)
Gene Namethymidylate synthetase
Gene Symbol TYMS
SynonymsTS; TMS; HST422;
Alternate namesthymidylate synthase; TSase;
Chromosome18
Map Location18p11.32
EC Number2.1.1.45;
SummaryThymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TYMS

Proteins

thymidylate synthase
Refseq ID:NP_001062
Protein GI:4507751
UniProt ID:P04818
mRNA ID:NM_001071
Length:313
RefSeq Status:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKE
LSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQ
FYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
 
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