MGP Database

MGP003229

Ontology/Pathway Information

Entrez Gene ID	7298
Gene Name	thymidylate synthetase
Gene Symbol	TYMS
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005743	IDA:UniProtKB	C	mitochondrial inner membrane
GO:0005759	IDA:UniProtKB	C	mitochondrial matrix
GO:0005739	IDA:UniProtKB	C	mitochondrion
GO:0005730	IEA:Ensembl	C	nucleolus
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0048037	IEA:Ensembl	F	cofactor binding
GO:0008144	IEA:Ensembl	F	drug binding
GO:0005542	IEA:Ensembl	F	folic acid binding
GO:0003729	IEA:Ensembl	F	mRNA binding
GO:0000166	IEA:Ensembl	F	nucleotide binding
GO:0004799	TAS:Reactome	F	thymidylate synthase activity
GO:0007568	IEA:Ensembl	P	aging
GO:0051216	IEA:Ensembl	P	cartilage development
GO:0007623	IEA:Ensembl	P	circadian rhythm
GO:0009157	TAS:ProtInc	P	deoxyribonucleoside monophosphate biosynthetic process
GO:0048589	IEA:Ensembl	P	developmental growth
GO:0006231	IEA:InterPro	P	dTMP biosynthetic process
GO:0006235	IEA:UniProtKB-UniPathway	P	dTTP biosynthetic process
GO:0046078	IEA:Ensembl	P	dUMP metabolic process
GO:0000082	TAS:Reactome	P	G1/S transition of mitotic cell cycle
GO:0019088	IEA:Ensembl	P	immortalization of host cell by virus
GO:0060574	IEA:Ensembl	P	intestinal epithelial cell maturation
GO:0000278	TAS:Reactome	P	mitotic cell cycle
GO:0006139	TAS:ProtInc	P	nucleobase-containing compound metabolic process
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0006206	TAS:Reactome	P	pyrimidine nucleobase metabolic process
GO:0046134	TAS:Reactome	P	pyrimidine nucleoside biosynthetic process
GO:0000083	TAS:Reactome	P	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0034097	IEA:Ensembl	P	response to cytokine
GO:0042493	IEA:Ensembl	P	response to drug
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0051593	IEA:Ensembl	P	response to folic acid
GO:0051384	IEA:Ensembl	P	response to glucocorticoid
GO:0046683	IEP:UniProtKB	P	response to organophosphorus
GO:0032570	IEA:Ensembl	P	response to progesterone
GO:0009636	IEA:Ensembl	P	response to toxic substance
GO:0033189	IEA:Ensembl	P	response to vitamin A
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0046653	IEA:Ensembl	P	tetrahydrofolate metabolic process
GO:0019860	IEA:Ensembl	P	uracil metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_115566	Cell Cycle
REACT_152	Cell Cycle, Mitotic
REACT_471	E2F mediated regulation of DNA replication
REACT_683	G1/S-Specific Transcription
REACT_1783	G1/S Transition
REACT_111217	Metabolism
REACT_1698	Metabolism of nucleotides
REACT_21267	Mitotic G1-G1/S phases
REACT_21376	Pyrimidine biosynthesis
REACT_957	Pyrimidine metabolism

SMP Pathway Links

SMP ID	Description
SMP00172	Beta Ureidopropionase Deficiency
SMP00469	Capecitabine Action Pathway
SMP00607	Capecitabine Metabolism Pathway
SMP00178	Dihydropyrimidinase Deficiency
SMP00470	Fluorouracil Action Pathway
SMP00608	Fluorouracil Metabolism Pathway
SMP00446	Gemcitabine Action Pathway
SMP00603	Gemcitabine Metabolism Pathway
SMP00202	MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
SMP00046	Pyrimidine Metabolism
SMP00219	UMP Synthase Deiciency (Orotic Aciduria)