MGP Database

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MGP003229

UniProt Annotations

Entry Information
Gene Namethymidylate synthetase
Protein EntryTYSY_HUMAN
UniProt IDP04818
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P04818-1; Sequence=Displayed; Name=2; Synonyms=delta4; IsoId=P04818-2; Sequence=VSP_047746; Note=Expressed both in normal and cancerous tissues.; Name=3; Synonyms=delta2+3; IsoId=P04818-3; Sequence=VSP_047745; Note=Expressed only in cancerous tissues.;
Catalytic Activity5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
FunctionContributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:21876188}.
PathwayPyrimidine metabolism; dTTP biosynthesis.
SimilarityBelongs to the thymidylate synthase family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:21876188}. Cytoplasm {ECO:0000269|PubMed:21876188}. Mitochondrion {ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}.
SubunitHomodimer.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TYMS";
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