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MGP003258

Record overview

MGPD IDMGP003258
Gene ID7351
SpeciesHomo sapiens (Human)
Gene Nameuncoupling protein 2 (mitochondrial, proton carrier)
Gene Symbol UCP2
SynonymsUCPH; BMIQ4; SLC25A8;
Alternate namesmitochondrial uncoupling protein 2; solute carrier family 25 member 8;
Chromosome11
Map Location11q13
SummaryMitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for UCP2

Proteins

mitochondrial uncoupling protein 2
Refseq ID:NP_003346
Protein GI:13259541
UniProt ID:P55851
mRNA ID:NM_003355
Length:309
RefSeq Status:
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLY
DSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLI
KDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA
ACTSREAPF
 
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