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MGP003258

UniProt Annotations

Entry Information
Gene Nameuncoupling protein 2 (mitochondrial, proton carrier)
Protein EntryUCP2_HUMAN
UniProt IDP55851
SpeciesHuman
Comments
Comment typeDescription
FunctionUCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
PolymorphismGenetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIM:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals.
SimilarityBelongs to the mitochondrial carrier (TC 2.A.29) family. {ECO:0000305}.
SimilarityContains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule:PRU00282}.
Subcellular LocationMitochondrion inner membrane; Multi-pass membrane protein.
SubunitActs as a dimer forming a proton channel. {ECO:0000250}.
Tissue SpecificityWidely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ucp2/";
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