MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003338

UniProt Annotations

Entry Information
Gene Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Protein Entry1433E_HUMAN
UniProt IDP62258
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62258-1; Sequence=Displayed; Name=SV; IsoId=P62258-2; Sequence=VSP_040621; Note=Unable to dimerize with YWHAZ.;
FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
InteractionO92972:- (xeno); NbExp=5; IntAct=EBI-356498, EBI-9213553; O14727:APAF1; NbExp=2; IntAct=EBI-356498, EBI-446492; O00257-3:CBX4; NbExp=2; IntAct=EBI-356498, EBI-4392727; O94921:CDK14; NbExp=3; IntAct=EBI-356498, EBI-1043945; Q9UKT5:FBXO4; NbExp=5; IntAct=EBI-356498, EBI-960409; P56524:HDAC4; NbExp=4; IntAct=EBI-356498, EBI-308629; Q14678-2:KANK1; NbExp=3; IntAct=EBI-356498, EBI-6173812; Q5S007:LRRK2; NbExp=6; IntAct=EBI-356498, EBI-5323863; Q99759:MAP3K3; NbExp=3; IntAct=EBI-356498, EBI-307281; O15151:MDM4; NbExp=3; IntAct=EBI-356498, EBI-398437; P58340:MLF1; NbExp=3; IntAct=EBI-356498, EBI-721328; O35244:Prdx6 (xeno); NbExp=2; IntAct=EBI-356498, EBI-915490; P61588:Rnd3 (xeno); NbExp=2; IntAct=EBI-356498, EBI-6930266; Q99469:STAC; NbExp=2; IntAct=EBI-356498, EBI-2652799; Q9GZV5:WWTR1; NbExp=3; IntAct=EBI-356498, EBI-747743; P31946:YWHAB; NbExp=3; IntAct=EBI-356498, EBI-359815; P61981:YWHAG; NbExp=4; IntAct=EBI-356498, EBI-359832; P63104:YWHAZ; NbExp=5; IntAct=EBI-356498, EBI-347088;
SimilarityBelongs to the 14-3-3 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Melanosome {ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitHomodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, ARHGEF28 and TIAM2 (By similarity). Interacts with HCV core protein. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with phosphorylated GRB10. Interacts with PKA-phosphorylated AANAT. Interacts with the phosphorylated (by AKT1) form of SRPK2. {ECO:0000250, ECO:0000269|PubMed:10644344, ECO:0000269|PubMed:11427721, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:15722337, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:17085597, ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491}.
  logo