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MGP003340

UniProt Annotations

Entry Information
Gene Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Protein Entry1433F_HUMAN
UniProt IDQ04917
SpeciesHuman
Comments
Comment typeDescription
FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
InteractionQ96B36:AKT1S1; NbExp=3; IntAct=EBI-306940, EBI-720593; Q8N5S9:CAMKK1; NbExp=5; IntAct=EBI-306940, EBI-6424030; P30305:CDC25B; NbExp=3; IntAct=EBI-306940, EBI-1051746; O94921:CDK14; NbExp=3; IntAct=EBI-306940, EBI-1043945; P67828:CSNK1A1 (xeno); NbExp=8; IntAct=EBI-306940, EBI-7540603; O60565:GREM1; NbExp=5; IntAct=EBI-306940, EBI-944395; P56524:HDAC4; NbExp=3; IntAct=EBI-306940, EBI-308629; Q14678-2:KANK1; NbExp=3; IntAct=EBI-306940, EBI-6173812; Q5S007:LRRK2; NbExp=3; IntAct=EBI-306940, EBI-5323863; Q7KZI7:MARK2; NbExp=8; IntAct=EBI-306940, EBI-516560; P27448:MARK3; NbExp=4; IntAct=EBI-306940, EBI-707595; Q96L34:MARK4; NbExp=6; IntAct=EBI-306940, EBI-302319; Q8TEW0:PARD3; NbExp=6; IntAct=EBI-306940, EBI-81968; Q9NPB6:PARD6A; NbExp=2; IntAct=EBI-306940, EBI-81876; Q9BYG5:PARD6B; NbExp=2; IntAct=EBI-306940, EBI-295391; Q9BYG4:PARD6G; NbExp=2; IntAct=EBI-306940, EBI-295417; P41743:PRKCI; NbExp=3; IntAct=EBI-306940, EBI-286199; P04049:RAF1; NbExp=3; IntAct=EBI-306940, EBI-365996; P61588:Rnd3 (xeno); NbExp=2; IntAct=EBI-306940, EBI-6930266;
PtmPhosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. {ECO:0000250}.
SimilarityBelongs to the 14-3-3 family. {ECO:0000305}.
SubunitHomodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation- dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1. {ECO:0000250, ECO:0000269|PubMed:11266503, ECO:0000269|PubMed:12177059, ECO:0000269|PubMed:14504289, ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:17085597, ECO:0000269|PubMed:19172738}.
Tissue SpecificityExpressed mainly in the brain and present in other tissues albeit at lower levels.
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