MGP Database

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MGP003605

Ontology/Pathway Information

Entrez Gene ID8566
Gene Namepyridoxal (pyridoxine, vitamin B6) kinase
Gene Symbol PDXK
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005524 IDA:UniProtKBFATP binding
GO:0031403 IDA:UniProtKBFlithium ion binding
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0030955 IDA:UniProtKBFpotassium ion binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0008478 IDA:UniProtKBFpyridoxal kinase activity
GO:0030170 IDA:UniProtKBFpyridoxal phosphate binding
GO:0031402 IDA:UniProtKBFsodium ion binding
GO:0008270 IDA:UniProtKBFzinc ion binding
GO:0008283 IDA:UniProtKBPcell proliferation
GO:0009443 IEA:InterProPpyridoxal 5'-phosphate salvage
GO:0042823 IDA:UniProtKBPpyridoxal phosphate biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0042816 IC:UniProtKBPvitamin B6 metabolic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_111217Metabolism
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_25012Vitamins B6 activation to pyridoxal phosphate
SMP Pathway Links
SMP IDDescription
SMP00503Hypophosphatasia
SMP00017Vitamin B6 Metabolism
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