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MGP003605

UniProt Annotations

Entry Information
Gene Namepyridoxal (pyridoxine, vitamin B6) kinase
Protein EntryPDXK_HUMAN
UniProt IDO00764
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O00764-1; Sequence=Displayed; Name=2; IsoId=O00764-2; Sequence=VSP_004653; Note=No experimental confirmation available.; Name=3; Synonyms=PKH-T; IsoId=O00764-3; Sequence=VSP_010671;
Biophysicochemical PropertiespH dependence: Optimum pH is 5.5-6.0.;
Catalytic ActivityATP + pyridoxal = ADP + pyridoxal 5'- phosphate.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Divalent metal cations. Zn(2+) is more efficient than Mg(2+).;
FunctionRequired for synthesis of pyridoxal-5-phosphate from vitamin B6.
SimilarityBelongs to the pyridoxine kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000305}.
Tissue SpecificityUbiquitous. Isoform 3 is detected in adult testis and spermatozoa.
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