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MGP003628

Record overview

MGPD IDMGP003628
Gene ID8644
SpeciesHomo sapiens (Human)
Gene Namealdo-keto reductase family 1, member C3
Gene Symbol AKR1C3
SynonymsDD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS;
Alternate namesaldo-keto reductase family 1 member C3; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); chlordecone reductase homolog HAKRb; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; indanol dehydrogenase; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase;
Chromosome10
Map Location10p15-p14
EC Number1.-.-.-
SummaryThis gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
OrthologsView orthologs and multiple alignments for AKR1C3

Proteins

aldo-keto reductase family 1 member C3 isoform 1
Refseq ID:NP_003730
Protein GI:24497583
UniProt ID:P42330
mRNA ID:NM_003739
Length:323
RefSeq Status:
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALE
NSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRS
KLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
 
aldo-keto reductase family 1 member C3 isoform 2
Refseq ID:NP_001240837
Protein GI:359806990
UniProt ID:P42330
mRNA ID:NM_001253908
Length:323
RefSeq Status:
MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALE
NSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRS
KLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
 
aldo-keto reductase family 1 member C3 isoform 3
Refseq ID:NP_001240838
Protein GI:359806998
UniProt ID:B4DKT3
mRNA ID:NM_001253909
Length:138
RefSeq Status:
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALE
NSLKKAQLDYVDLYLIHSPMSLKVCSLYEHKIALLLSL
 
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