MGP Database

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MGP003628

Ontology/Pathway Information

Entrez Gene ID8644
Gene Namealdo-keto reductase family 1, member C3
Gene Symbol AKR1C3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005622 IDA:LIFEdbCintracellular
GO:0005634 IDA:UniProtKBCnucleus
GO:0047020 IDA:UniProtKBF15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0004032 IDA:UniProtKBFalditol:NADP+ 1-oxidoreductase activity
GO:0004033 TAS:UniProtKBFaldo-keto reductase (NADP) activity
GO:0047023 IDA:UniProtKBFandrosterone dehydrogenase activity
GO:0047787 IDA:UniProtKBFdelta4-3-oxosteroid 5beta-reductase activity
GO:0035410 IDA:UniProtKBFdihydrotestosterone 17-beta-dehydrogenase activity
GO:0045550 IDA:UniProtKBFgeranylgeranyl reductase activity
GO:0047718 IEA:UniProtKB-ECFindanol dehydrogenase activity
GO:0045703 IDA:UniProtKBFketoreductase activity
GO:0047086 IDA:UniProtKBFketosteroid monooxygenase activity
GO:0016655 IDA:UniProtKBFoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 IDA:UniProtKBFphenanthrene 9,10-monooxygenase activity
GO:0036131 IEA:UniProtKB-ECFprostaglandin D2 11-ketoreductase activity
GO:0047017 IEA:UniProtKB-ECFprostaglandin-F synthase activity
GO:0001758 IDA:UniProtKBFretinal dehydrogenase activity
GO:0004745 IDA:UniProtKBFretinol dehydrogenase activity
GO:0047045 IEA:UniProtKB-ECFtestosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047035 IEA:UniProtKB-ECFtestosterone dehydrogenase (NAD+) activity
GO:0047115 IEA:UniProtKB-ECFtrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0019369 TAS:ReactomeParachidonic acid metabolic process
GO:0071276 IDA:UniProtKBPcellular response to cadmium ion
GO:0071277 IDA:UniProtKBPcellular response to calcium ion
GO:0071384 IDA:UniProtKBPcellular response to corticosteroid stimulus
GO:0071395 IDA:UniProtKBPcellular response to jasmonic acid stimulus
GO:0071799 IDA:UniProtKBPcellular response to prostaglandin D stimulus
GO:0071379 IDA:UniProtKBPcellular response to prostaglandin stimulus
GO:0034614 IDA:UniProtKBPcellular response to reactive oxygen species
GO:0009267 IEP:UniProtKBPcellular response to starvation
GO:0019371 TAS:ReactomePcyclooxygenase pathway
GO:0044597 IMP:UniProtKBPdaunorubicin metabolic process
GO:0044598 IMP:UniProtKBPdoxorubicin metabolic process
GO:0016488 IDA:UniProtKBPfarnesol catabolic process
GO:0007186 IDA:UniProtKBPG-protein coupled receptor signaling pathway
GO:0030216 IEP:UniProtKBPkeratinocyte differentiation
GO:0008584 IEP:UniProtKBPmale gonad development
GO:0044259 IEP:UniProtKBPmulticellular organismal macromolecule metabolic process
GO:1900053 IDA:UniProtKBPnegative regulation of retinoic acid biosynthetic process
GO:0055114 IDA:UniProtKBPoxidation-reduction process
GO:0007603 TAS:ReactomePphototransduction, visible light
GO:0010942 IDA:UniProtKBPpositive regulation of cell death
GO:0008284 IDA:UniProtKBPpositive regulation of cell proliferation
GO:2000353 IDA:UniProtKBPpositive regulation of endothelial cell apoptotic process
GO:0051897 IDA:UniProtKBPpositive regulation of protein kinase B signaling
GO:2000379 IDA:UniProtKBPpositive regulation of reactive oxygen species metabolic process
GO:0042448 IDA:UniProtKBPprogesterone metabolic process
GO:0006693 IEP:UniProtKBPprostaglandin metabolic process
GO:0000060 IDA:UniProtKBPprotein import into nucleus, translocation
GO:0048385 IDA:UniProtKBPregulation of retinoic acid receptor signaling pathway
GO:2000224 IMP:UniProtKBPregulation of testosterone biosynthetic process
GO:0070293 NAS:UniProtKBPrenal absorption
GO:0007584 IEP:UniProtKBPresponse to nutrient
GO:0042574 IDA:UniProtKBPretinal metabolic process
GO:0001523 TAS:ReactomePretinoid metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 IEP:UniProtKBPsteroid metabolic process
GO:0061370 IMP:UniProtKBPtestosterone biosynthetic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_11040Bile acid and bile salt metabolism
REACT_116125Disease
REACT_160102Diseases associated with visual transduction
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_268561RA biosynthesis pathway
REACT_24968Retinoid metabolism and transport
REACT_267785Signaling by Retinoic Acid
REACT_111102Signal Transduction
REACT_11054Synthesis of bile acids and bile salts
REACT_11053Synthesis of bile acids and bile salts via 24-hydroxycholesterol
REACT_11048Synthesis of bile acids and bile salts via 27-hydroxycholesterol
REACT_11041Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
REACT_150149Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
REACT_160125Visual phototransduction
SMP Pathway Links
SMP IDDescription
SMP00710Acetaminophen Action Pathway
SMP00083Acetylsalicylic Acid Action Pathway
SMP00692Antipyrine Action Pathway
SMP00693Antrafenine Action Pathway
SMP00075Arachidonic Acid Metabolism
SMP00102Bromfenac Action Pathway
SMP00694Carprofen Action Pathway
SMP00096Celecoxib Action Pathway
SMP00093Diclofenac Action Pathway
SMP00289Diflunisal Action Pathway
SMP00650Doxorubicin Metabolism Pathway
SMP00084Etodolac Action Pathway
SMP00695Etoricoxib Action Pathway
SMP00696Fenoprofen Action Pathway
SMP00697Flurbiprofen Action Pathway
SMP00086Ibuprofen Action Pathway
SMP00104Indomethacin Action Pathway
SMP00085Ketoprofen Action Pathway
SMP00098Ketorolac Action Pathway
SMP00353Leukotriene C4 Synthesis Deficiency
SMP00700Lornoxicam Action Pathway
SMP00699Lumiracoxib Action Pathway
SMP00698Magnesium salicylate Action Pathway
SMP00109Mefenamic Acid Action Pathway
SMP00106Meloxicam Action Pathway
SMP00114Nabumetone Action Pathway
SMP00120Naproxen Action Pathway
SMP00702Nepafenac Action Pathway
SMP00113Oxaprozin Action Pathway
SMP00701Phenylbutazone Action Pathway
SMP00077Piroxicam Action Pathway
SMP00087Rofecoxib Action Pathway
SMP00708Salicylate-sodium Action Pathway
SMP00709Salicylic Acid Action Pathway
SMP00707Salsalate Action Pathway
SMP00094Sulindac Action Pathway
SMP00101Suprofen Action Pathway
SMP00706Tenoxicam Action Pathway
SMP00705Tiaprofenic Acid Action Pathway
SMP00704Tolmetin Action Pathway
SMP00703Trisalicylate-choline Action Pathway
SMP00116Valdecoxib Action Pathway
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