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MGP003651

Record overview

MGPD IDMGP003651
Gene ID8692
SpeciesHomo sapiens (Human)
Gene Namehyaluronoglucosaminidase 2
Gene Symbol HYAL2
SynonymsLUCA2;
Alternate nameshyaluronidase-2; PH-20 homolog; PH20 homolog; hyal-2; hyaluronidase 2; hyaluronoglucosaminidase-2; lung carcinoma protein 2; lysosomal hyaluronidase;
Chromosome3
Map Location3p21.3
EC Number3.2.1.35
SummaryThis gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for HYAL2

Proteins

hyaluronidase-2 precursor
Refseq ID:NP_003764
Protein GI:15022801
UniProt ID:Q12891
mRNA ID:NM_003773
Length:473
RefSeq Status:
MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGV
PQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPR
HLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSR
RLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGH
APGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2010
peptide sequence: 
MRAGPGPTVTLALVLAVSWA

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2010
peptide sequence: 
MRAGPGPTVTLALVLAVSWA
 
hyaluronidase-2 precursor
Refseq ID:NP_149348
Protein GI:34304377
UniProt ID:Q12891
mRNA ID:NM_033158
Length:473
RefSeq Status:
Protein sequence is identical to GI:15022801 (mRNA isoform)
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2010
peptide sequence: 
MRAGPGPTVTLALVLAVSWA
 
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