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MGP003651

UniProt Annotations

Entry Information

Gene Name	hyaluronoglucosaminidase 2
Protein Entry	HYAL2_HUMAN
UniProt ID	Q12891
Species	Human

Comments

Comment type	Description
Catalytic Activity	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Caution	Was originally thought to be lysosomal. {ECO:0000305}.
Function	Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. {ECO:0000269\|PubMed:11296287, ECO:0000269\|PubMed:12676986, ECO:0000269\|PubMed:9712871}.
Sequence Caution	Sequence=AAC28656.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the glycosyl hydrolase 56 family. {ECO:0000305}.
Similarity	Contains 1 EGF-like domain. {ECO:0000305}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:11296287}; Lipid-anchor, GPI-anchor {ECO:0000269\|PubMed:11296287}.
Subunit	Interacts with MST1R. {ECO:0000269\|PubMed:12676986}.
Tissue Specificity	Widely expressed. No expression detected in adult brain. {ECO:0000269\|PubMed:9712871}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HYAL2ID40904ch3p21.html";