MGP Database

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MGP003651

Ontology/Pathway Information

Entrez Gene ID8692
Gene Namehyaluronoglucosaminidase 2
Gene Symbol HYAL2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031362 IDA:UniProtKBCanchored component of external side of plasma membrane
GO:0046658 IDA:UniProtKBCanchored component of plasma membrane
GO:0016324 IDA:UniProtKBCapical plasma membrane
GO:0009986 IDA:UniProtKBCcell surface
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0016023 IDA:UniProtKBCcytoplasmic membrane-bounded vesicle
GO:0031410 IDA:UniProtKBCcytoplasmic vesicle
GO:0005829 IDA:BHF-UCLCcytosol
GO:0030139 IDA:BHF-UCLCendocytic vesicle
GO:0005783 NAS:UniProtKBCendoplasmic reticulum
GO:0000139 ISS:UniProtKBCGolgi membrane
GO:0005764 IDA:UniProtKBClysosome
GO:0045121 IDA:UniProtKBCmembrane raft
GO:0005902 IDA:BHF-UCLCmicrovillus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005886 TAS:ReactomeCplasma membrane
GO:0090575 ISS:BHF-UCLCRNA polymerase II transcription factor complex
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0005540 IDA:UniProtKBFhyaluronic acid binding
GO:0033906 IDA:UniProtKBFhyaluronoglucuronidase activity
GO:0004415 IDA:UniProtKBFhyalurononglucosaminidase activity
GO:0030294 IDA:UniProtKBFreceptor signaling protein tyrosine kinase inhibitor activity
GO:0030971 IPI:UniProtKBFreceptor tyrosine kinase binding
GO:0050431 ISS:BHF-UCLFtransforming growth factor beta binding
GO:0001618 IDA:UniProtKBFvirus receptor activity
GO:0005975 TAS:ReactomePcarbohydrate metabolic process
GO:0051216 IEP:UniProtKBPcartilage development
GO:0044344 IDA:UniProtKBPcellular response to fibroblast growth factor stimulus
GO:0071347 IDA:UniProtKBPcellular response to interleukin-1
GO:0071560 IDA:BHF-UCLPcellular response to transforming growth factor beta stimulus
GO:0071356 IEP:UniProtKBPcellular response to tumor necrosis factor
GO:0071493 IDA:UniProtKBPcellular response to UV-B
GO:0051607 IEA:EnsemblPdefense response to virus
GO:0019064 IDA:UniProtKBPfusion of virus membrane with host plasma membrane
GO:0006027 IDA:UniProtKBPglycosaminoglycan catabolic process
GO:0030203 TAS:ReactomePglycosaminoglycan metabolic process
GO:0002244 IEA:EnsemblPhematopoietic progenitor cell differentiation
GO:0030214 IDA:UniProtKBPhyaluronan catabolic process
GO:0030212 TAS:ReactomePhyaluronan metabolic process
GO:0001822 ISS:UniProtKBPkidney development
GO:0042117 IDA:UniProtKBPmonocyte activation
GO:0010259 IEA:EnsemblPmulticellular organismal aging
GO:0060586 IEA:EnsemblPmulticellular organismal iron ion homeostasis
GO:0030308 IDA:UniProtKBPnegative regulation of cell growth
GO:0010764 IDA:UniProtKBPnegative regulation of fibroblast migration
GO:0043407 IDA:UniProtKBPnegative regulation of MAP kinase activity
GO:0051898 IDA:UniProtKBPnegative regulation of protein kinase B signaling
GO:0061099 IDA:UniProtKBPnegative regulation of protein tyrosine kinase activity
GO:2001238 ISS:BHF-UCLPpositive regulation of extrinsic apoptotic signaling pathway
GO:0050729 IDA:UniProtKBPpositive regulation of inflammatory response
GO:2000778 IDA:UniProtKBPpositive regulation of interleukin-6 secretion
GO:2000484 IDA:UniProtKBPpositive regulation of interleukin-8 secretion
GO:0042307 ISS:BHF-UCLPpositive regulation of protein import into nucleus
GO:0045944 ISS:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0035810 ISS:UniProtKBPpositive regulation of urine volume
GO:0070295 ISS:UniProtKBPrenal water absorption
GO:0046677 IEP:UniProtKBPresponse to antibiotic
GO:0000302 IDA:UniProtKBPresponse to reactive oxygen species
GO:0009615 IDA:UniProtKBPresponse to virus
GO:0048705 IEA:EnsemblPskeletal system morphogenesis
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0019087 IDA:UniProtKBPtransformation of host cell by virus
GO:0046718 ISS:UniProtKBPviral entry into host cell
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_268678Defective B3GAT3 causes JDSSDHD
REACT_268431Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268749Defective B4GALT7 causes EDS, progeroid type
REACT_267917Defective CHST14 causes EDS, musculocontractural type
REACT_267648Defective CHST3 causes SEDCJD
REACT_268786Defective CHST6 causes MCDC1
REACT_268113Defective CHSY1 causes TPBS
REACT_267942Defective EXT1 causes exostoses 1, TRPS2 and CHDS
REACT_267741Defective EXT2 causes exostoses 2
REACT_268843Defective PAPSS2 causes SEMD-PA
REACT_268059Defective SLC26A2 causes chondrodysplasias
REACT_116125Disease
REACT_268624Diseases associated with glycosaminoglycan metabolism
REACT_268324Diseases of glycosylation
REACT_264090Glycogen storage diseases
REACT_121315Glycosaminoglycan metabolism
REACT_121083Hyaluronan metabolism
REACT_120996Hyaluronan uptake and degradation
REACT_111217Metabolism
REACT_474Metabolism of carbohydrates
REACT_147857MPS I - Hurler syndrome
REACT_147734MPS II - Hunter syndrome
REACT_147753MPS IIIA - Sanfilippo syndrome A
REACT_147788MPS IIIB - Sanfilippo syndrome B
REACT_147860MPS IIIC - Sanfilippo syndrome C
REACT_147749MPS IIID - Sanfilippo syndrome D
REACT_147825MPS IV - Morquio syndrome A
REACT_147798MPS IV - Morquio syndrome B
REACT_147739MPS IX - Natowicz syndrome
REACT_147759MPS VII - Sly syndrome
REACT_147719MPS VI - Maroteaux-Lamy syndrome
REACT_147853Mucopolysaccharidoses
REACT_264430Myoclonic epilepsy of Lafora
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