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MGP003672

Record overview

MGPD IDMGP003672
Gene ID8743
SpeciesHomo sapiens (Human)
Gene Nametumor necrosis factor (ligand) superfamily, member 10
Gene Symbol TNFSF10
SynonymsTL2; APO2L; CD253; TRAIL; Apo-2L;
Alternate namestumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta;
Chromosome3
Map Location3q26
SummaryThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
OrthologsView orthologs and multiple alignments for TNFSF10

Proteins

tumor necrosis factor ligand superfamily member 10 isoform 1
Refseq ID:NP_003801
Protein GI:4507593
UniProt ID:P50591
mRNA ID:NM_003810
Length:281
RefSeq Status:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETI
STVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENT
KNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
 
tumor necrosis factor ligand superfamily member 10 isoform 2
Refseq ID:NP_001177871
Protein GI:300193032
UniProt ID:P50591
mRNA ID:NM_001190942
Length:101
RefSeq Status:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKTPRMKRLWAA
K
 
tumor necrosis factor ligand superfamily member 10 isoform 3
Refseq ID:NP_001177872
Protein GI:300193034
UniProt ID:
mRNA ID:NM_001190943
Length:65
RefSeq Status:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQFAENDCQRLMSGQQTGSLLPS
 
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