MGP Database

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MGP003672

UniProt Annotations

Entry Information
Gene Nametumor necrosis factor (ligand) superfamily, member 10
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50591-1; Sequence=Displayed; Name=2; Synonyms=TRAIL-short, TRAIL-s; IsoId=P50591-2; Sequence=VSP_043507, VSP_043508; Note=Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B).;
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per trimer.;
FunctionCytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
InteractionQ13618:CUL3; NbExp=2; IntAct=EBI-495373, EBI-456129; O00220:TNFRSF10A; NbExp=4; IntAct=EBI-495373, EBI-518861; O14763:TNFRSF10B; NbExp=21; IntAct=EBI-495373, EBI-518882;
PtmTyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
SimilarityBelongs to the tumor necrosis factor family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
SubunitHomotrimer.
Tissue SpecificityWidespread; most predominant in spleen, lung and prostate.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TNFSF10ID42632ch3q26.html";
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