MGP Database

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MGP003672

Ontology/Pathway Information

Entrez Gene ID8743
Gene Nametumor necrosis factor (ligand) superfamily, member 10
Gene Symbol TNFSF10
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IEA:UniProtKB-KWCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0005102 TAS:ProtIncFreceptor binding
GO:0006919 TAS:ReactomePactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915 TAS:ReactomePapoptotic process
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0006955 IEA:InterProPimmune response
GO:0008584 IEA:EnsemblPmale gonad development
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0043280 IDA:UniProtKBPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001238 IDA:UniProtKBPpositive regulation of extrinsic apoptotic signaling pathway
GO:0043123 IEP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0090200 IDA:UniProtKBPpositive regulation of release of cytochrome c from mitochondria
GO:2001239 TAS:ReactomePregulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0032868 IEA:EnsemblPresponse to insulin
GO:0007165 TAS:ProtIncPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_578Apoptosis
REACT_1503Caspase-8 activation by cleavage
REACT_1619Death Receptor Signalling
REACT_832Dimerization of procaspase-8
REACT_1059Extrinsic Pathway
REACT_268456Programmed Cell Death
REACT_164011Regulation by c-FLIP
REACT_402TRAIL signaling
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