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MGP Database

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MGP003712

UniProt Annotations

Entry Information

Gene Name	suppressor of cytokine signaling 2
Protein Entry	SOCS2_HUMAN
UniProt ID	O14508
Species	Human

Comments

Comment type	Description
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Induction	By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF.
Interaction	P19235:EPOR; NbExp=3; IntAct=EBI-617737, EBI-617321; P10721:KIT; NbExp=4; IntAct=EBI-617737, EBI-1379503; Q15369:TCEB1; NbExp=2; IntAct=EBI-617737, EBI-301231;
Pathway	Protein modification; protein ubiquitination.
Similarity	Contains 1 SH2 domain. {ECO:0000255\|PROSITE- ProRule:PRU00191}.
Similarity	Contains 1 SOCS box domain. {ECO:0000255\|PROSITE- ProRule:PRU00194}.
Subunit	Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. {ECO:0000269\|PubMed:16675548}.
Tissue Specificity	High expression in heart, placenta, lung, kidney and prostate.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SOCS2ID44123ch12q21.html";