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MGP003906

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase omega 1
Protein EntryGSTO1_HUMAN
UniProt IDP78417
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P78417-1; Sequence=Displayed; Name=2; IsoId=P78417-2; Sequence=VSP_045820; Name=3; IsoId=P78417-3; Sequence=VSP_045819;
Biophysicochemical PropertiespH dependence: Optimum pH is 8. {ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937};
Catalytic Activity2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Catalytic ActivityMethylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
Catalytic ActivityRX + glutathione = HX + R-S-glutathione.
Enzyme RegulationMonomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
FunctionExhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}.
InteractionP04792:HSPB1; NbExp=2; IntAct=EBI-712083, EBI-352682;
Sequence CautionSequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the GST superfamily. Omega family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:11511179}.
SubunitHomodimer. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:21106529}.
Tissue SpecificityUbiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. {ECO:0000269|PubMed:10783391}.
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