MGP Database

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MGP003941

UniProt Annotations

Entry Information
Gene Nameprostaglandin E synthase
Protein EntryPTGES_HUMAN
UniProt IDO14684
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate. {ECO:0000269|PubMed:18682561}.
CofactorName=glutathione; Xref=ChEBI:CHEBI:57925; Evidence={ECO:0000269|PubMed:18682561};
FunctionCatalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). {ECO:0000269|PubMed:18682561}.
InductionBy p53/TP53. {ECO:0000269|PubMed:9305847}.
SimilarityBelongs to the MAPEG family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000269|PubMed:18682561}; Multi-pass membrane protein {ECO:0000269|PubMed:18682561}.
SubunitHomotrimer. {ECO:0000269|PubMed:23431194}.
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