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MGP004179

Record overview

MGPD IDMGP004179
Gene ID10253
SpeciesHomo sapiens (Human)
Gene Namesprouty homolog 2 (Drosophila)
Gene Symbol SPRY2
SynonymshSPRY2;
Alternate namesprotein sprouty homolog 2; sprouty 2; spry-2;
Chromosome13
Map Location13q31.1
SummaryThis gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SPRY2

Proteins

protein sprouty homolog 2
Refseq ID:NP_005833
Protein GI:5032115
UniProt ID:O43597
mRNA ID:NM_005842
Length:315
RefSeq Status:
MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVH
SSARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWI
CDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVC
CKVPTVPPRNFEKPT
 
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