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MGP004179

UniProt Annotations

Entry Information
Gene Namesprouty homolog 2 (Drosophila)
Protein EntrySPY2_HUMAN
UniProt IDO43597
SpeciesHuman
Comments
Comment typeDescription
DomainThe Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. {ECO:0000269|PubMed:10887178}.
FunctionMay function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. {ECO:0000269|PubMed:10887178}.
InductionBy FGF signaling.
InteractionP22681:CBL; NbExp=17; IntAct=EBI-742487, EBI-518228; P62993:GRB2; NbExp=3; IntAct=EBI-742487, EBI-401755; Q96B97:SH3KBP1; NbExp=2; IntAct=EBI-742487, EBI-346595;
PtmCleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro). {ECO:0000269|PubMed:21288888}.
SimilarityBelongs to the sprouty family. {ECO:0000305}.
SimilarityContains 1 SPR (sprouty) domain. {ECO:0000255|PROSITE- ProRule:PRU00572}.
Subcellular LocationCytoplasm, cytoskeleton {ECO:0000269|PubMed:10887178}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10887178}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).
SubunitInteracts with RAF1. {ECO:0000269|PubMed:12717443}.
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