MGP Database

MGP004179

Ontology/Pathway Information

Entrez Gene ID	10253
Gene Name	sprouty homolog 2 (Drosophila)
Gene Symbol	SPRY2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0005874	IEA:UniProtKB-KW	C	microtubule
GO:0015630	IDA:HPA	C	microtubule cytoskeleton
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0032587	IEA:UniProtKB-SubCell	C	ruffle membrane
GO:0019901	IPI:BHF-UCL	F	protein kinase binding
GO:0043539	IMP:UniProtKB	F	protein serine/threonine kinase activator activity
GO:0030291	IC:BHF-UCL	F	protein serine/threonine kinase inhibitor activity
GO:0060449	IEA:Ensembl	P	bud elongation involved in lung branching
GO:0045165	IEA:Ensembl	P	cell fate commitment
GO:0007173	TAS:Reactome	P	epidermal growth factor receptor signaling pathway
GO:0000132	IEA:Ensembl	P	establishment of mitotic spindle orientation
GO:0008543	TAS:Reactome	P	fibroblast growth factor receptor signaling pathway
GO:0042472	IEA:Ensembl	P	inner ear morphogenesis
GO:0060437	IEA:Ensembl	P	lung growth
GO:0043066	IMP:UniProtKB	P	negative regulation of apoptotic process
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0042059	TAS:Reactome	P	negative regulation of epidermal growth factor receptor signaling pathway
GO:0070373	IEA:Ensembl	P	negative regulation of ERK1 and ERK2 cascade
GO:0040037	IEA:Ensembl	P	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0043407	IEA:Ensembl	P	negative regulation of MAP kinase activity
GO:0051387	IEA:Ensembl	P	negative regulation of neurotrophin TRK receptor signaling pathway
GO:0010801	IDA:BHF-UCL	P	negative regulation of peptidyl-threonine phosphorylation
GO:0034261	IEA:Ensembl	P	negative regulation of Ras GTPase activity
GO:0046580	IEA:Ensembl	P	negative regulation of Ras protein signal transduction
GO:0070374	IMP:UniProtKB	P	positive regulation of ERK1 and ERK2 cascade
GO:0010628	IMP:UniProtKB	P	positive regulation of gene expression
GO:0033138	IMP:UniProtKB	P	positive regulation of peptidyl-serine phosphorylation
GO:0051897	IMP:UniProtKB	P	positive regulation of protein kinase B signaling
GO:0071902	IMP:GOC	P	positive regulation of protein serine/threonine kinase activity
GO:0007605	IEA:Ensembl	P	sensory perception of sound

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_116125	Disease
REACT_12484	EGFR downregulation
REACT_111184	Negative regulation of FGFR signaling
REACT_9417	Signaling by EGFR
REACT_115871	Signaling by EGFR in Cancer
REACT_268269	Signaling by EGFRvIII in Cancer
REACT_9470	Signaling by FGFR
REACT_120736	Signaling by FGFR in disease
REACT_268006	Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546	Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_111102	Signal Transduction
REACT_111080	Spry regulation of FGF signaling