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MGP004297

Record overview

MGPD IDMGP004297
Gene ID10588
SpeciesHomo sapiens (Human)
Gene Name5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Gene Symbol MTHFS
SynonymsHsT19268;
Alternate names5-formyltetrahydrofolate cyclo-ligase; methenyl-THF synthetase;
Chromosome15
Map Location15q25.1
EC Number6.3.3.2
SummaryThe protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
OrthologsView orthologs and multiple alignments for MTHFS

Proteins

5-formyltetrahydrofolate cyclo-ligase isoform a
Refseq ID:NP_006432
Protein GI:5453746
UniProt ID:P49914
mRNA ID:NM_006441
Length:203
RefSeq Status:
MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEE
ISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDS
STA
 
5-formyltetrahydrofolate cyclo-ligase isoform b
Refseq ID:NP_001186687
Protein GI:315113868
UniProt ID:P49914
mRNA ID:NM_001199758
Length:146
RefSeq Status:
MQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYL
KRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA
 
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