MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004297

UniProt Annotations

Entry Information
Gene Name5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Protein EntryMTHFS_HUMAN
UniProt IDP49914
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49914-1; Sequence=Displayed; Name=2; IsoId=P49914-2; Sequence=VSP_046863; Note=No experimental confirmation available.;
Catalytic ActivityATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
FunctionContributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}.
Sequence CautionSequence=CK002935; Type=Frameshift; Positions=178, 201; Evidence={ECO:0000305};
SimilarityBelongs to the 5-formyltetrahydrofolate cyclo-ligase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitMonomer.
  logo