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MGP004361

Record overview

MGPD IDMGP004361
Gene ID10797
SpeciesHomo sapiens (Human)
Gene Namemethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Gene Symbol MTHFD2
SynonymsNMDMC;
Alternate namesbifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase;
Chromosome2
Map Location2p13.1
EC Number1.5.1.15
SummaryThis gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for MTHFD2

Proteins

bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor
Refseq ID:NP_006627
Protein GI:94721354
UniProt ID:P13995
mRNA ID:NM_006636
Length:350
RefSeq Status:
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSE
TIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAG
RSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
 
transit_peptide: 1..29
calculated_mol_wt: 3151
peptide sequence: 
MAATSLMSALAARLLQPAHSCSLRLRPFH

mat_peptide: 30..350
product: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
calculated_mol_wt: 34762
peptide sequence: 
LAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGL
LVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVT
ISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK
KVLRLEEREVLKSKELGVATN
 
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