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MGP004361

UniProt Annotations

Entry Information
Gene Namemethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Protein EntryMTDC_HUMAN
UniProt IDP13995
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13995-1; Sequence=Displayed; Name=2; IsoId=P13995-2; Sequence=VSP_056188;
Catalytic Activity5,10-methenyltetrahydrofolate + H(2)O = 10- formyltetrahydrofolate.
Catalytic Activity5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Developmental StageExpressed only in developing normal tissues.
InteractionQ9Y6F1:PARP3; NbExp=1; IntAct=EBI-1058895, EBI-1045281; Q9UNM6:PSMD13; NbExp=1; IntAct=EBI-1058895, EBI-356070;
MiscellaneousThis NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD.
Sequence CautionSequence=AAX93061.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96546.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96761.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA34431.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. {ECO:0000305}.
Subcellular LocationMitochondrion.
SubunitHomodimer.
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