MGP Database

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MGP004361

Ontology/Pathway Information

Entrez Gene ID10797
Gene Namemethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Gene Symbol MTHFD2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005739 ISS:UniProtKBCmitochondrion
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0004477 ISS:UniProtKBFmethenyltetrahydrofolate cyclohydrolase activity
GO:0004487 IDA:UniProtKBFmethylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 IDA:UniProtKBFmethylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0042301 IDA:UniProtKBFphosphate ion binding
GO:0009396 IEA:InterProPfolic acid-containing compound biosynthetic process
GO:0006730 IBA:GO_CentralPone-carbon metabolic process
GO:0046653 IDA:UniProtKBPtetrahydrofolate metabolic process
SMP Pathway Links
SMP IDDescription
SMP00724Folate malabsorption, hereditary
SMP00053Folate Metabolism
SMP00543Homocystinuria due to defect of N(5,10)-methylene THF deficiency
SMP00432Methotrexate Action Pathway
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