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MGP004479

Record overview

MGPD IDMGP004479
Gene ID11197
SpeciesHomo sapiens (Human)
Gene NameWNT inhibitory factor 1
Gene Symbol WIF1
SynonymsWIF-1;
Alternate nameswnt inhibitory factor 1;
Chromosome12
Map Location12q14.3
SummaryThe protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for WIF1

Proteins

wnt inhibitory factor 1 precursor
Refseq ID:NP_009122
Protein GI:111125011
UniProt ID:Q9Y5W5
mRNA ID:NM_007191
Length:379
RefSeq Status:
MARRSAFPAAALWLWSILLCLLALRAEAGPPQEESLYLWIDAHQARVLIGFEEDILIVSEGKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYF
YEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDVIVMNSEGNTILQTPQNAIFFKTCQQAECPGGCRNGGFCNERRICEC
PDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGY
QGDLCSKPVCEPGCGAHGTCHEPNKCQCQEGWHGRHCNKRYEASLIHALRPAGAQLRQHTPSLKKAEERRDPPESNYIW
 
sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3115
peptide sequence: 
MARRSAFPAAALWLWSILLCLLALRAEA
 
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