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MGP004514

Record overview

MGPD IDMGP004514
Gene ID11343
SpeciesHomo sapiens (Human)
Gene Namemonoglyceride lipase
Gene Symbol MGLL
SynonymsMGL; HUK5; MAGL; HU-K5;
Alternate namesmonoglyceride lipase; lysophospholipase homolog; monoacylglycerol lipase;
Chromosome3
Map Location3q21.3
EC Number3.1.1.23
SummaryThis gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
OrthologsView orthologs and multiple alignments for MGLL

Proteins

monoglyceride lipase isoform 1
Refseq ID:NP_009214
Protein GI:6005786
UniProt ID:Q99685
mRNA ID:NM_007283
Length:313
RefSeq Status:
METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVV
SDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTE
VDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWV
SQRTATAGTASPP
 
monoglyceride lipase isoform 2
Refseq ID:NP_001003794
Protein GI:51242953
UniProt ID:Q99685
mRNA ID:NM_001003794
Length:303
RefSeq Status:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDV
LQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLI
CRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
 
monoglyceride lipase isoform 3
Refseq ID:NP_001243514
Protein GI:375268702
UniProt ID:Q99685
mRNA ID:NM_001256585
Length:283
RefSeq Status:
METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVV
SDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVDIYNSDPLICRAGLKVCFGIQLLNAVSRV
ERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
 
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