MGP Database

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MGP004514

UniProt Annotations

Entry Information
Gene Namemonoglyceride lipase
Protein EntryMGLL_HUMAN
UniProt IDQ99685
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99685-1; Sequence=Displayed; Name=2; IsoId=Q99685-2; Sequence=VSP_045138, VSP_045139;
Catalytic ActivityHydrolyzes glycerol monoesters of long-chain fatty acids.
FunctionConverts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. {ECO:0000250, ECO:0000269|PubMed:20079333}.
MiscellaneousShort-term inhibition causes analgesia, while long- term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity. {ECO:0000250}.
PathwayGlycerolipid metabolism; triacylglycerol degradation.
Sequence CautionSequence=AAB39616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH00551.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH06230.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG37910.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAG33116.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW79330.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW79331.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the AB hydrolase superfamily. Monoacylglycerol lipase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:19957260, ECO:0000269|PubMed:19962385}.
Tissue SpecificityDetected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}.
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