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MGP004679

Record overview

MGPD IDMGP004679
Gene ID23462
SpeciesHomo sapiens (Human)
Gene Namehes-related family bHLH transcription factor with YRPW motif 1
Gene Symbol HEY1
SynonymsCHF2; OAF1; HERP2; HESR1; HRT-1; hHRT1; BHLHb31;
Alternate nameshairy/enhancer-of-split related with YRPW motif protein 1; HES-related repressor protein 1; HES-related repressor protein 2; basic helix-loop-helix protein OAF1; cardiovascular helix-loop-helix factor 2; class B basic helix-loop-helix protein 31; hairy and enhancer of split-related protein 1; hairy-related transcription factor 1; hairy/enhancer-of-split related with YRPW motif 1;
Chromosome8
Map Location8q21
SummaryThis gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HEY1

Proteins

hairy/enhancer-of-split related with YRPW motif protein 1 isoform a
Refseq ID:NP_036390
Protein GI:105990528
UniProt ID:Q9Y5J3
mRNA ID:NM_012258
Length:304
RefSeq Status:
MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDH
LKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNG
HGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTE
IGAF
 
hairy/enhancer-of-split related with YRPW motif protein 1 isoform b
Refseq ID:NP_001035798
Protein GI:105990526
UniProt ID:Q9Y5J3
mRNA ID:NM_001040708
Length:308
RefSeq Status:
MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQM
TVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLL
PQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP
WGTEIGAF
 
hairy/enhancer-of-split related with YRPW motif protein 1 isoform c
Refseq ID:NP_001269780
Protein GI:544583479
UniProt ID:Q9Y5J3
mRNA ID:NM_001282851
Length:214
RefSeq Status:
MPLEERNVFWLSKGNLTGDQGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHI
AHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANL
GKPYRPWGTEIGAF
 
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