MGP Database

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MGP004679

Ontology/Pathway Information

Entrez Gene ID23462
Gene Namehes-related family bHLH transcription factor with YRPW motif 1
Gene Symbol HEY1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 ISS:UniProtKBCnucleus
GO:0035939 IDA:UniProtKBFmicrosatellite binding
GO:0000988 IDA:UniProtKBFprotein binding transcription factor activity
GO:0000983 ISS:UniProtKBFRNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0008134 NAS:UniProtKBFtranscription factor binding
GO:0001525 IEP:UniProtKBPangiogenesis
GO:0009948 IEA:EnsemblPanterior/posterior axis specification
GO:0060842 ISS:BHF-UCLParterial endothelial cell differentiation
GO:0003190 ISS:BHF-UCLPatrioventricular valve formation
GO:0060317 ISS:BHF-UCLPcardiac epithelial to mesenchymal transition
GO:0060411 ISS:BHF-UCLPcardiac septum morphogenesis
GO:0003208 ISS:BHF-UCLPcardiac ventricle morphogenesis
GO:0071385 IEA:EnsemblPcellular response to glucocorticoid stimulus
GO:0035912 ISS:BHF-UCLPdorsal aorta morphogenesis
GO:0003203 ISS:BHF-UCLPendocardial cushion morphogenesis
GO:0003199 IEA:EnsemblPendocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003198 ISS:UniProtKBPepithelial to mesenchymal transition involved in endocardial cushion formation
GO:0060347 ISS:BHF-UCLPheart trabecula formation
GO:0060716 ISS:BHF-UCLPlabyrinthine layer blood vessel development
GO:0045746 IDA:BHF-UCLPnegative regulation of Notch signaling pathway
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:2000820 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2000678 IDA:BHF-UCLPnegative regulation of transcription regulatory region DNA binding
GO:0061314 IC:BHF-UCLPNotch signaling involved in heart development
GO:0007219 IDA:UniProtKBPNotch signaling pathway
GO:0002076 IEA:EnsemblPosteoblast development
GO:0045669 IEA:EnsemblPpositive regulation of osteoblast differentiation
GO:0045944 ISS:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0003184 ISS:BHF-UCLPpulmonary valve morphogenesis
GO:2001212 ISS:BHF-UCLPregulation of vasculogenesis
GO:0006366 ISS:GOCPtranscription from RNA polymerase II promoter
GO:0036304 ISS:BHF-UCLPumbilical cord morphogenesis
GO:0001570 IEA:EnsemblPvasculogenesis
GO:0060412 ISS:BHF-UCLPventricular septum morphogenesis
GO:0003222 IEA:EnsemblPventricular trabecula myocardium morphogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_111102Signal Transduction
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