MGP Database

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MGP004679

UniProt Annotations

Entry Information
Gene Namehes-related family bHLH transcription factor with YRPW motif 1
Protein EntryHEY1_HUMAN
UniProt IDQ9Y5J3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5J3-1; Sequence=Displayed; Name=2; IsoId=Q9Y5J3-2; Sequence=VSP_040997;
FunctionDownstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867}.
SimilarityBelongs to the HEY family. {ECO:0000305}.
SimilarityContains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255|PROSITE-ProRule:PRU00981}.
SimilarityContains 1 Orange domain. {ECO:0000255|PROSITE- ProRule:PRU00380}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
SubunitSelf-associates. Interacts with HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with CCDC89/BOIP. {ECO:0000250}.
Tissue SpecificityExpressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.
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