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MGP004761

Record overview

MGPD IDMGP004761
Gene ID25805
SpeciesHomo sapiens (Human)
Gene NameBMP and activin membrane-bound inhibitor
Gene Symbol BAMBI
SynonymsNMA;
Alternate namesBMP and activin membrane-bound inhibitor homolog; non-metastatic gene A protein; putative transmembrane protein NMA;
Chromosome10
Map Location10p12.3-p11.2
SummaryThis gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for BAMBI

Proteins

BMP and activin membrane-bound inhibitor homolog precursor
Refseq ID:NP_036474
Protein GI:6912534
UniProt ID:Q13145
mRNA ID:NM_012342
Length:260
RefSeq Status:
MDRHSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAKQARNHSGTTIPTLECCH
EDMCNYRGLHDVLSPPRGEASGQGNRYQHDGSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHG
HHSKKGQVAKLDLECMVPVSGHENCCLTCDKMRQADLSNDKILSLVHWGMYSGHGKLEFV
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2428
peptide sequence: 
MDRHSSYIFIWLQLELCAMA

mat_peptide: 21..260
product: BMP and activin membrane-bound inhibitor homolog
calculated_mol_wt: 26698
peptide sequence: 
VLLTKGEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAKQARNHSGTTIPTLECCHEDMCNYRGLHDVLSPPRGEA
SGQGNRYQHDGSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHHSKKGQVAKLDLECMVPVS
GHENCCLTCDKMRQADLSNDKILSLVHWGMYSGHGKLEFV
 
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