MGP Database

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MGP004761

UniProt Annotations

Entry Information
Gene NameBMP and activin membrane-bound inhibitor
Protein EntryBAMBI_HUMAN
UniProt IDQ13145
SpeciesHuman
Comments
Comment typeDescription
Developmental StageExpression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.
FunctionNegatively regulates TGF-beta signaling.
SimilarityBelongs to the BAMBI family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue SpecificityHigh expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
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