MGP Database

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MGP004959

Record overview

MGPD IDMGP004959
Gene ID27306
SpeciesHomo sapiens (Human)
Gene Namehematopoietic prostaglandin D synthase
Gene Symbol HPGDS
SynonymsGSTS; PGD2; PGDS; GSTS1; GSTS1-1;
Alternate nameshematopoietic prostaglandin D synthase; GST class-sigma; glutathione S-transferase sigma; glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; glutathione-requiring prostaglandin D synthase; hematopoietic prostaglandin D2 synthase; prostaglandin-H2 D-isomerase;
Chromosome4
Map Location4q22.3
EC Number5.3.99.2
SummaryProstaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HPGDS

Proteins

hematopoietic prostaglandin D synthase
Refseq ID:NP_055300
Protein GI:7657457
UniProt ID:O60760
mRNA ID:NM_014485
Length:199
RefSeq Status:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMS
CFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
 
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