MGP Database

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MGP004959

Ontology/Pathway Information

Entrez Gene ID27306
Gene Namehematopoietic prostaglandin D synthase
Gene Symbol HPGDS
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:ProtIncCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005509 IDA:UniProtKBFcalcium ion binding
GO:0004364 IEA:UniProtKB-ECFglutathione transferase activity
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0004667 IDA:UniProtKBFprostaglandin-D synthase activity
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0019369 TAS:ReactomeParachidonic acid metabolic process
GO:0019371 TAS:ReactomePcyclooxygenase pathway
GO:1901687 TAS:ReactomePglutathione derivative biosynthetic process
GO:0007626 TAS:ProtIncPlocomotory behavior
GO:0006693 IDA:UniProtKBPprostaglandin metabolic process
GO:0007165 NAS:ProtIncPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_13433Biological oxidations
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_6926Glutathione conjugation
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_6959Phase II conjugation
REACT_150149Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
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