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MGP005087

Record overview

MGPD IDMGP005087
Gene ID50855
SpeciesHomo sapiens (Human)
Gene Namepar-6 family cell polarity regulator alpha
Gene Symbol PARD6A
SynonymsPAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha;
Alternate namespartitioning defective 6 homolog alpha; PAR-6 alpha; Tax-interacting protein 40; par-6 partitioning defective 6 homolog alpha; partitioning defective-6 homolog alpha; partitioning-defective protein 6; tax interaction protein 40;
Chromosome16
Map Location16q22.1
SummaryThis gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PARD6A

Proteins

partitioning defective 6 homolog alpha isoform 1
Refseq ID:NP_058644
Protein GI:8394417
UniProt ID:Q9NPB6
mRNA ID:NM_016948
Length:346
RefSeq Status:
MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADS
SGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRG
GLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQ
GPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL
 
partitioning defective 6 homolog alpha isoform 2
Refseq ID:NP_001032358
Protein GI:82659097
UniProt ID:Q9NPB6
mRNA ID:NM_001037281
Length:345
RefSeq Status:
MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKREADSS
GLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGG
LAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQG
PPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL
 
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