MGP Database

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MGP005087

Ontology/Pathway Information

Entrez Gene ID50855
Gene Namepar-6 family cell polarity regulator alpha
Gene Symbol PARD6A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045177 IEA:EnsemblCapical part of cell
GO:0005938 IEA:EnsemblCcell cortex
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 ISS:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0043234 IEA:EnsemblCprotein complex
GO:0001726 IEA:UniProtKB-SubCellCruffle
GO:0005923 ISS:UniProtKBCtight junction
GO:0030742 ISS:UniProtKBFGTP-dependent protein binding
GO:0017048 ISS:UniProtKBFRho GTPase binding
GO:0008134 TAS:ProtIncFtranscription factor binding
GO:0045217 ISS:UniProtKBPcell-cell junction maintenance
GO:0045216 TAS:ReactomePcell-cell junction organization
GO:0007049 IEA:UniProtKB-KWPcell cycle
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0034329 TAS:ReactomePcell junction assembly
GO:0070830 TAS:ReactomePtight junction assembly
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0016032 TAS:ProtIncPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264478Asymmetric localization of PCP proteins
REACT_264224beta-catenin independent WNT signaling
REACT_111155Cell-Cell communication
REACT_19331Cell-cell junction organization
REACT_20676Cell junction organization
REACT_116125Disease
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_264199PCP/CE pathway
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_19373Tight junction interactions
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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