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MGP005087

UniProt Annotations

Entry Information
Gene Namepar-6 family cell polarity regulator alpha
Protein EntryPAR6A_HUMAN
UniProt IDQ9NPB6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPB6-1; Sequence=Displayed; Name=2; IsoId=Q9NPB6-2; Sequence=VSP_007459;
DomainThe OPR domain mediates interactions with MAP2K5. {ECO:0000250}.
DomainThe PDZ domain mediates the interaction with CRB3. {ECO:0000269|PubMed:14718572}.
DomainThe pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. {ECO:0000250}.
FunctionAdapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269|PubMed:10873802}.
InteractionP60953:CDC42; NbExp=7; IntAct=EBI-81876, EBI-81752; P33151:CDH5; NbExp=4; IntAct=EBI-81876, EBI-2903122; Q8TEW0:PARD3; NbExp=8; IntAct=EBI-81876, EBI-81968; Q8ND90:PNMA1; NbExp=2; IntAct=EBI-81876, EBI-302345; P41743:PRKCI; NbExp=11; IntAct=EBI-81876, EBI-286199; Q05513:PRKCZ; NbExp=6; IntAct=EBI-81876, EBI-295351; P63000:RAC1; NbExp=2; IntAct=EBI-81876, EBI-413628; Q04917:YWHAH; NbExp=2; IntAct=EBI-81876, EBI-306940;
PtmPhosphorylated by the TGF-beta receptor. {ECO:0000250}.
SimilarityBelongs to the PAR6 family. {ECO:0000305}.
SimilarityContains 1 OPR domain. {ECO:0000305}.
SimilarityContains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule:PRU00143}.
SimilarityContains 1 pseudo-CRIB domain. {ECO:0000305}.
Subcellular LocationCytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note=Colocalizes with GTP- bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.
SubunitInteracts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr- 359' phosphorylated form) and PRKCI. {ECO:0000250, ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:11257119, ECO:0000269|PubMed:11260256, ECO:0000269|PubMed:12545177, ECO:0000269|PubMed:14718572, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15590654, ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:9482110}.
Tissue SpecificityExpressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
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