Summary of Study ST001848

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001165. The data can be accessed directly via it's Project DOI: 10.21228/M8411V This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001848
Study TitleUntargeted mass spectrometry reveals impact of high fat diet on peripheral amino acid regulation in a mouse model of Alzheimer’s Disease
Study Typeuntargeted metabolomics analysis
Study SummaryAPPSwe/PS1ΔE9 (APP/PSEN1) transgenic mice (to represent familial or early-onset AD) and wild-type litter mater controls were fed either a high-fat diet (HFD, 60% kcal from lard), low-fat diet (LFD, 10% kcal from lard) from 2 months of age, or reversal diet (REV, high-fat followed by low-fat from 9.5 months).
Institute
Vanderbilt University
DepartmentChemistry
LaboratoryCenter for Innovative Technology
Last NameCodreanu
First NameSimona
Address3009, Liberty Hills Drive
EmailSIMONA.CODREANU@VANDERBILT.EDU
Phone6153477458
Submit Date2021-06-03
Num Groups6
Total Subjects36
Num Males18
Num Females18
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Simona Codreanu Simona Codreanu
https://dx.doi.org/10.21228/M8411V
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO001918
Collection Summary:Liver samples from male and female APPSwe/PS1ΔE9 (APP/PSEN1) transgenic mice and wild-type (WT) littermates were collected after sacrifice at 12 months. These mice are a subset of mice for which behavioral and biochemical data have already been published, including weight change and diabetic state as assessed by glucose tolerance tests.After sacrifice, liver tissue samples were taken and put immediately on dry ice and stored at −80°C until used in the analytical workflow described herein.
Sample Type:Liver
Storage Conditions:-80℃
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