Summary of Study ST001848
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001165. The data can be accessed directly via it's Project DOI: 10.21228/M8411V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001848 |
| Study Title | Untargeted mass spectrometry reveals impact of high fat diet on peripheral amino acid regulation in a mouse model of Alzheimer’s Disease |
| Study Type | untargeted metabolomics analysis |
| Study Summary | APPSwe/PS1ΔE9 (APP/PSEN1) transgenic mice (to represent familial or early-onset AD) and wild-type litter mater controls were fed either a high-fat diet (HFD, 60% kcal from lard), low-fat diet (LFD, 10% kcal from lard) from 2 months of age, or reversal diet (REV, high-fat followed by low-fat from 9.5 months). |
| Institute | Vanderbilt University |
| Department | Chemistry |
| Laboratory | Center for Innovative Technology |
| Last Name | Codreanu |
| First Name | Simona |
| Address | 3009, Liberty Hills Drive |
| SIMONA.CODREANU@VANDERBILT.EDU | |
| Phone | 6153477458 |
| Submit Date | 2021-06-03 |
| Num Groups | 6 |
| Total Subjects | 36 |
| Num Males | 18 |
| Num Females | 18 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-08-31 |
| Release Version | 1 |
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Project:
| Project ID: | PR001165 |
| Project DOI: | doi: 10.21228/M8411V |
| Project Title: | Untargeted mass spectrometry reveals impact of high fat diet on peripheral amino acid regulation in a mouse model of Alzheimer’s Disease |
| Project Type: | Untargeted Metabolomics analysis |
| Project Summary: | Recent research regarding amino acid metabolism has shown that there may be a link between obesity and Alzheimer’s Disease (AD). This work reports a metabolomics study using untargeted mass spectrometry-based metabolomic strategies to investigate the metabolic changes that occur in AD and obesity. APPSwe/PS1ΔE9 (APP/PSEN1) transgenic mice (to represent familial or early-onset AD) and wild-type litter mater controls were fed either a high-fat diet (HFD, 60% kcal from lard), low-fat diet (LFD, 10% kcal from lard) from 2 months of age, or reversal diet (REV, high-fat followed by low-fat from 9.5 months). |
| Institute: | Vanderbilt University |
| Department: | Chemistry |
| Laboratory: | Center for Innovative Technology |
| Last Name: | Codreanu |
| First Name: | Simona |
| Address: | 3009, Liberty Hills Drive |
| Email: | SIMONA.CODREANU@VANDERBILT.EDU |
| Phone: | 6153477458 |
