Summary of Study ST000881
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000611. The data can be accessed directly via it's Project DOI: 10.21228/M8XQ41 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST000881 |
| Study Title | Targeted metabolomics data of leprosy patients with type 1 reaction |
| Study Type | Targeted MS/MS analysis in retrospective serum samples of leprosy patients with type 1 reaction |
| Study Summary | Targeted metabolomics-based analyses of pooled sera from 7 patients with T1R were conducted via LC-MS/MS. |
| Institute | Colorado State University |
| Department | Department of Microbiology, Immunology, and Pathology |
| Laboratory | Belisle |
| Last Name | Silva |
| First Name | Carlos |
| Address | Rampart Road, 1682 Campus Delivery |
| cadriano@rams.colostate.edu | |
| Phone | 9702154962 |
| Submit Date | 2017-08-02 |
| Num Groups | 2 |
| Total Subjects | 16 |
| Num Males | 5 |
| Num Females | 11 |
| Study Comments | 2 groups (first group was leprosy patients with type 1 reaction, N=9; and second group was leprosy patients without type 1 reaction, N=7) 5 males (3 were leprosy patients with type 1 reaction and 2 were leprosy patients without type 1 reaction), 11 females (4 were leprosy patients with type 1 reaction and 7 were leprosy patients without type 1 reaction). For this study we used retrospective sera samples. |
| Publications | J Infect Dis. 2017 Feb 1;215(3):431-439. doi: 10.1093/infdis/jiw541. |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2017-08-02 |
| Release Version | 1 |
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Project:
| Project ID: | PR000611 |
| Project DOI: | doi: 10.21228/M8XQ41 |
| Project Title: | Metabolomics analysis of leprosy patients with type 1 reaction |
| Project Type: | MS qualitative analysis and identification of polyunsaturated fatty acids in retrospective serum samples of leprosy patients with type 1 reaction |
| Project Summary: | Type 1 reaction (T1R) is an acute inflammatory episode that causes severe neuronal damages in patients with leprosy. The factors that trigger this pathology is still unknown, and further studies are needed to understand T1R and to early prevent its start. It is well established that the host immune response is linked to T1R and previous studies indicated that the metabolism of the host also influences the adaptive immune response against M. leprae antigens. Therefore, metabolomics-based analyses of sera from 7 patients with and 9 without T1R were conducted via liquid chromatography–mass spectrometry. The main goal of this project was to determine whether the metabolism of polyunsaturated fatty acids (such as eicosanoids and omega-3 fatty acids) were perturbed in leprosy patients with T1R. |
| Institute: | Colorado State University |
| Department: | Department of Microbiology, Immunology, and Pathology |
| Laboratory: | Belisle |
| Last Name: | Belisle |
| First Name: | John |
| Address: | Rampart Road, 1682 Campus Delivery |
| Email: | cadriano@rams.colostate.edu |
| Phone: | 9704819160 |
| Funding Source: | This work was supported by the New York Community Trust (grant to J. T. B. as co–principle investigator [PI]), by the Heiser Foundation (grant to J. T. B. as co-PI), and by the Brazilian Coordination for the Improvement of Higher Education Personnel through the Science without Borders program (10546-13-8, for the postdoctoral scholarship to C. A. M. S.). |
| Project Comments: | The institutional review boards of Colorado State University approved the use of sera for the reported study. |
| Publications: | J Infect Dis. 2017 Feb 1;215(3):431-439. doi: 10.1093/infdis/jiw541. |
| Contributors: | Carlos A. M. Silva, Kristofor Webb, Barbara G. Andre, Maria Angela Marques, Fernanda Marques Carvalho, Cristiana Santos de Macedo, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Maria Cristina Vidal Pessolani, John T. Belisle. |
